Is Dilaudid addictive, or is it just another opioid?

Dilaudid is the brand name for hydromorphone, an opioid prescribed for severe pain and given in hospitals by injection or as a tablet. Milligram for milligram it is more potent than morphine, and the body adapts to it the way it adapts to any opioid.

This page is by Dr. Leeds, an osteopathic physician in Fort Lauderdale who treats opioid dependence by telemedicine for patients in Florida.

So, is Dilaudid addictive? Is it worse than oxycodone? Is it safer because a hospital gave it to you? It can be addictive, and the same tablets also produce physical dependence in pain patients who never took one pill more than they were prescribed.

Exalgo, the extended-release brand of hydromorphone, has been discontinued in the United States. Yet, immediate-release hydromorphone, as Dilaudid and its generics, is still prescribed every day, so this question is not going away.

Whether your Dilaudid came from a surgeon, a pain clinic, or the street, the day eventually arrives when you want to stop. What happens then?

Physical dependence on Dilaudid is not the same as addiction.

Physical dependence means the body has adapted to the opioid and will go into withdrawal without it. It happens to pain patients who never misused a pill, and it is not addiction.

Addiction is a compulsive pattern of use that continues despite harm. When that pattern is present alongside dependence, both problems deserve treatment, and neither one is a moral failing.

Unfortunately, the older way of thinking treated every person who could not stop as someone in denial who needed an intervention. While a pain patient who cannot stop hydromorphone is physically dependent, they are not in denial, and a diagnosis is not a confession.

So, coming off Dilaudid is not a program intake. It begins with an honest medical evaluation. A doctor needs to know how much you are taking and for how long, whether it began as pain treatment, and what else you take.

And, the doctor needs to know what you actually want, whether that is stopping completely, stabilizing, or something not yet decided. Many people arrive at this question directly from the pain clinic, and that history shapes the plan rather than counting against you.

Are there withdrawal symptoms when quitting Dilaudid?

Yes, and they are not milder than withdrawal from any other opioid. Patients have told doctors for years that Dilaudid is easier to quit than heroin or oxycodone, but hydromorphone has a full withdrawal syndrome of its own, and it can be every bit as bad.

Sweating, yawning, tearing eyes, muscle aches, stomach cramps, diarrhea, insomnia, and a restless anxiety that makes the hours crawl all arrive within a day or so of the last dose, along with strong cravings. While opioid withdrawal is terrible, it is rarely dangerous by itself in an otherwise healthy adult.

The danger comes afterward. Imagine someone who has carried the same heavy box up the stairs every morning for years, and then takes a month off. The box has not changed, but the person has, and the first lift is the one that injures them.

While this is not a perfect analogy, opioid tolerance works the same way. It falls within days of stopping, and a person who goes back to a dose that felt ordinary a month earlier can stop breathing, which is why opioid withdrawal is more dangerous than it looks. An opioid overdose is an emergency, and the right response is to call 911 first and sort out the rest later.

How does treatment start?

Usually with buprenorphine, the medication in Suboxone and ZubSolv, because Dilaudid dependence is treated like any other opioid dependence. Buprenorphine is a partial opioid agonist, meaning it occupies the same receptors as hydromorphone firmly enough to stop withdrawal and cravings without the peaks and crashes of a full opioid.

While its ceiling effect makes dangerous respiratory depression far less likely than with hydromorphone, less likely is not impossible. Combined with alcohol, benzodiazepines, or other sedatives it can still slow breathing, and the Dilaudid prescribing information carries the same warning about mixing opioids with benzodiazepines.

If you take a prescribed benzodiazepine, tell the doctor at the first visit. Do not stop it on your own, because stopping a benzodiazepine suddenly can cause seizures, and both prescribers need to know about each other.

Is there a certification to look for? Not anymore. Since January 2023 a doctor has not needed a federal waiver to prescribe buprenorphine, so the question is whether the doctor does this work regularly. A certificate on the wall proves nothing.

Do you have to be in withdrawal before starting buprenorphine?

Not always. Because buprenorphine holds the receptor more tightly than hydromorphone, the traditional method is to wait until early withdrawal has begun before the first dose, so that the new medication does not push the old one off the receptor all at once and set off a sudden, precipitated withdrawal.

Fortunately, there is another way for people who are still taking hydromorphone, or whose supply may contain fentanyl. A low-dose start, sometimes called microdosing or the Bernese method, builds buprenorphine up gradually over several days before the old opioid is stopped, so that you need not enter full withdrawal first.

From there the plan follows your goals. Some patients stabilize on buprenorphine for years, and others move toward a gradual, patient-paced taper once life is steady, where rushing is the most common mistake. An overview of the medications used to treat opioid dependence shows how the options compare, and both paths are legitimate.

What about methadone or naltrexone?

Methadone is the other established medication for opioid dependence, and it works. Yet, for this purpose it is dispensed through licensed opioid treatment programs rather than from a private doctor’s office, which is why buprenorphine is the office-based path.

Naltrexone is different in kind. It is a blocker rather than a replacement, and it can only be started after a person has been completely off opioids for a week or more, so it does nothing for withdrawal and cannot be the way through it.

For a patient who has been off hydromorphone for a while and wants protection against a return, naltrexone is a fair conversation to have. For a patient in withdrawal today, it is the wrong tool.

Does withdrawal have to be endured at all?

With buprenorphine, most of what withdrawal does to a person is prevented rather than endured. That is the whole point of the medication, and it is why the miserable week on the bathroom floor is not a required step.

In fact, Dilaudid’s own prescribing information tells doctors not to stop the drug abruptly, or reduce it rapidly, in a patient who is physically dependent, because doing so has caused serious withdrawal symptoms, uncontrolled pain, and in some cases suicide. The label is asking for a taper. That is the right request.

If coming off of an opioid has brought on thoughts of suicide, call or text 988 today. That is not something to save for the next appointment.

That week is sometimes treated as the price of admission. It is not a price. It is a hazard, because tolerance drops during it, and the first return to use afterward is when overdoses happen.

Should Dilaudid be taken off the market as a pain reliever?

No. Hydromorphone is an effective medication for severe pain, and it has an important place in acute and chronic pain management, in the hospital and outside it.

While some patients develop dependence, and some develop addiction, that is a reason to prescribe it with an exit plan. It is not a reason to take it away from the people it helps, and the patient who needs it for pain and the patient who needs help getting off of it are often the same person at two points in time.

Both deserve a doctor who can tell the difference and treat what is actually in front of them. The drug is neither harmless nor evil.

What else needs treatment besides the opioid?

Many people with opioid dependence also carry anxiety, depression, chronic pain, or a few hard years that have not been sorted out. Fortunately, treatment holds better when those are addressed as part of ongoing medical care rather than set aside for later, and depression during buprenorphine treatment is common enough to deserve its own conversation.

Family members help most with patience. Cutting a person off to teach them a lesson does not push them toward treatment. It pushes them toward the overdose that follows a stretch of lost tolerance.

There are no mandatory group meetings in this kind of care. A patient who finds a meeting helpful may of course keep going, but attendance is not a condition of medical treatment, and a person whose only problem is physical dependence does not need a recovery curriculum.

Dr. Leeds treats Dilaudid dependence from a private telemedicine practice.

Dr. Leeds is an osteopathic physician in Fort Lauderdale with over two decades of experience in treating medication and drug dependence and addiction. He prescribes buprenorphine (Suboxone and its film and tablet generics) to new patients throughout Florida by telemedicine, with in-office visits available in Fort Lauderdale. Induction is done at home with phone support, and, when fentanyl is involved, with a low-dose start where it is needed. Visits are monthly, and weekly when a patient needs more, and every visit is with Dr. Leeds himself. He does not offer long-acting injectables such as Sublocade or Vivitrol as a service, although he can advise on them in a consultation. He does not run a separate counseling program either, though he counsels and coaches patients as part of their medical care and refers out when more is needed. There are no fixed timelines, and a family member or advocate invited by the patient is welcome at a visit, never required. The details of Suboxone treatment in Fort Lauderdale are on the service page.

The first step is a conversation. So, if you are in Florida and want to talk through where you are with hydromorphone and what a safe start would look like, contact Dr. Leeds through the contact form. A consultation is not a medical visit and does not establish a physician-patient relationship.

This article is educational. It is not medical advice, and reading it does not create a doctor-patient relationship. Decisions about starting, continuing, or tapering any medication should be made with your own physician.

Dilaudid Addiction Treatment: Abuse, Withdrawal & Symptoms Fort Lauderdale FL